Glowing brain tumour trial begins

By James Gallagher Health reporter
BBC News

 

The tumour glows under UV light

The idea of making brain cancers glow to help surgeons operate is being tested in the UK.

Patients will be given a drug, 5-amino-levulinic acid (5-ALA), which causes a build-up of fluorescent chemicals in the tumour.

The theory is that the pink glow will clearly mark the edges of the tumour, making it easier to ensure all of it is removed.

More than 60 patients with glioblastoma will take part in the trial.

They have cancerous glial cells, which normally hold the brain's nerves cells in place. On average patients survive 15 months after being diagnosed.

No room for error
 
In some cancers, such as those of the colon, some of the surrounding tissue can be removed as well as the tumour. Removing a brain tumour needs to be more precise.

“Treating brain tumours is a real challenge facing clinicians and we urgently need new treatments”

Kate Law Cancer Research UK

 

Dr Colin Watts, who is leading the trial at the University of Cambridge, told the BBC that surgeons "don't want to take too much functional tissue away".

The trial will then test whether applying drugs directly to the tumour improves survival rates.

After the tumour has been removed under UV light, a thin drug-soaked wafer will be placed in the space left behind. This should slowly release chemotherapy drugs over four to six weeks to kill any remaining cancerous cells.

This could overcome one of the challenges with chemotherapy for brain tumours.

Dr Watts said: "One of the problems with chemotherapy is we don't actually know the extent a drug penetrates a tumour because of the blood brain barrier."

By applying the drug directly to the tumour it should be at a higher dose.

Charles Meacock, 56, from Norfolk, who has already taken part in the trial, said: "Hopefully it will benefit me, but will also help people in my situation in the future.

"It's four weeks since my surgery and my recovery seems to be going as it should. I just have to wait and see now."

The study has been funded by the Samantha Dickson Brain Tumour Trust and Cancer Research UK.

The founder of the Samantha Dickson Brain Tumour Trust, Neil Dickson, said he was proud to be funding the trial.

"Brain tumour research receives a fraction of the funding of that of higher profile cancers and it is our priority to redress the balance," he added.

Kate Law, Cancer Research UK's director of clinical research, said: "Treating brain tumours is a real challenge facing clinicians and we urgently need new treatments to help more people diagnosed with the disease."

Trials involving more patients will take place if this one is successful.

Indian woman has football-sized tumour removed from jaw

Photograph released by the All India Institute of Medical Sciences (AIIMS) ...


An Indian woman has had a tumour as big as a football removed from the side of her face, 25 years after it first developed.

Doctors who performed the operation believe 67-year-old Lakhmani Devi's parotid gland tumour, which weighed nearly two kilogrammes, may have been the biggest ever removed from a human.

"It was made of solid tissue and was the largest I have come across in all the medical books," K.K. Handa, the operating surgeon at New Delhi's All India Institute of Medical Sciences, told AFP on Monday.

"The patient was told by doctors in her village that she would die if it was removed so she coped with it for decades. But she is now eating well and should make a full recovery."

Devi, from the eastern state of Jharkhand, is expected to be discharged from hospital 10 days after the surgery on February 4.

Her son, Lallan Singh, said that the operation would give his mother a new lease of life.

"The tumour kept on increasing," he said. "She felt uncomfortable and embarrassed and stopped going out of the house. We can't thank the doctors enough."

Flashback: Chinese Man With Record 33-Pound Facial Tumor Survives Surgery

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